Investigative Procedures Assignment Example | Topics and Well Written Essays - 1250 words

Investigative Procedures - Assignment Example The allegations against the accused must be verified independently to ascertain reasonable grounds for further investigations. Once this is done, the CEO and CFO must be informed. Using a suitable team for instance the manufacturing plants' accounts department, documents should reviewed for any evidence. Investigations should then proceed to neutral persons then to third parties to corroborate evidence. Care should be taken not to violate suspect’s rights or break the law in seeking evidence and the truth. Introduction Internal fraud is becoming a common problem in organizations today because the employees have knowledge of the internal mechanisms and procedures for the organization. Some are in charge of divisions and so influence decisions and can manipulate by abusing their positions to commit internal fraud and thefts and still be able to cover their tracks. The employees may also leak information to outsiders who then use that information to commit frauds and the employee gets a payoff for their services. Employee fraud incidences have been on a steep incline especially during and immediately after the global financial crisis. The US for instance reported employee fraud that cost firms a total of $ 994 billion. The UK CIFAS data show that staff fraud increased by 40% since 2008 and the trends are interesting because it is the younger employees who are reportedly committing more crimes (Cohen, 2011). The same report also showed a 63% increase in staff fraud in 2011, compared to 2008 with fraud statistics in 2010 showing that staff fraudsters were mostly youngsters with 29% being under the age of 21 years while those aged between 41 – 50 years making up just 30% while no instance of internal fraud was reported for those above age 50 (Cohen, 2011). This paper will answer various questions and thereafter make a conclusion 1. Given the situation, discuss some of the options the company has for handling this situation.   This is obviously a preca rious situation since the plant manager gets a lot of respect from the CEO and CFO and their families are very close. However being close to the CEO and CFO should not stop investigations from taking place since this would amount to complicity and cover-ups by the top management. The investigator should be a senior manager for instance the Human Resources manager or the Legal advisor; since the crime is just alleged at this point. Certain facts should be ascertained to meet a specific threshold before in depth investigations can be carried out with the plant operator being interviewed and maybe being forced to go on leave pending investigations. To avoid upsetting the existing relations and causing too much friction, the signs and evidence of internal fraud must be established. These include accounting anomalies, weaknesses in internal controls, analytical symptoms, lifestyle symptoms, behavioral systems and employee tips and complaints. From the given scenario, Mr. Reynolds should consider the case serious and warranting an investigation since he has already received a tip from an employee in that plant, that the plant operator is exhibiting an erratic personal behavior while his lifestyle has changed beyond his normal means. Care must be taken to protect the identity of the informer (Goldman, 2007). Mr. Reynolds should then obtain prior evidence from the relevant person’s incognito and write a report, and request a report from the informer. An auditor or accounts

HPV in women Research Paper Example | Topics and Well Written Essays - 2000 words

HPV in women - Research Paper Example HPV in women Direct skin contact with an HPV infected person is the main way through which genital HPV occurs. The contact areas are the anal, vaginal, and oral sex. The diverse categories of HPV are responsible for the formation of genital warts on the skin. Genital warts are hard and usually rough lumps that become visible on the skin of a sick person. Any sexually active person is prone to acquire the virus and the genital warts. The genital warts in women predominantly appear around or inside the vagina, around or inside the anus, on the vulva, on the groin and on the cervix (Monsonego 37). Classification and morphology The human papilloma viruses are heterogeneous in nature. They affect both the mucosal epithelial tissues and the skin. Besides, they are hugely responsible for causing the cervical carcinogenesis. According to the results of the studies in molecular biology, more than one hundred genotypes of the virus exist in humans. The virus falls under two classifications mai nly the low risk HPV (LR-HPV and the high risk HPV (HR-HPV). The low risk HPV is predominant in squamous intraepithelial lesions (LSILs) with low grades and the benign lesions. Meanwhile, the high risk HPV includes the HPV-16 and HPV-18. Other high-risk HPV types include HPV-31, 33, 35, 39, 45, 51, 52, 55, 56, 58, 66, 68, and 70 (Evans and Kaslow 602). The high risk HPV has 80 to 90 per cent prevalence rate in cervical cancer and the squamous intraepithelial lesions (HSILs). In the morphological dimension, the genome of the papilloma virus is covalently circular and closed. Its DNA is double stranded and has a measurement of about 8kbp. All the genes of the papilloma virus are coded in the strands that define DNA. Through this, it utilizes the alternative DNA strand to splice the expression of individual gene. The expression of the papilloma virus has a characteristic of large mRNAs array of cells that code for diverse gene types. Additionally, the HPV has a diameter of 55nm (Evans and Kaslow 602). Molecular Biology and Replication Strategy The HPV contamination begins with the infection of the host cell. This promotes the discharge of the virus from the nucleus. As this happens, there are interactions of many cellular transcription factors. These interactions occur with the viral regulatory region (LRC) that does not code. As a result, the two HPV-16 begin to transcript and transforms earlier genes of E6 and E7. Consequently, the proteins that continue to transform interact with the cellular antioncogenic regulator p53. This action results in the disruption of the cell cycle. The cell cycle is under the regulation of the complexes of cyclin dependent kinases (CDKs) and the cyclins (Evans and Kaslow 692). The CDK complexes always inhibit the action of the cyclin. It is a condition for cells to pass the restriction point of G1 in order for the progression of the cell cycle (Evans and Kaslow 692). Retinoblastoma pockets bacteria, RB, p 107, and p 130 are the one s that regulate this process. There is only an indication in the RB leaving the other pocket proteins with the same functions and activities. In essence, they inactivate and bind up the E2F transcription factors. This leads to the inducement of the S phase genes expression that will trigger a mitogenic signal. This signal leads to the activation of the cyclin D1-CDK6 and cyclin D1-CDK4 complexes. The result of this is the